{"id":10952,"date":"2018-07-16T14:54:58","date_gmt":"2018-07-16T18:54:58","guid":{"rendered":"https:\/\/medicarereport.org\/?p=10952"},"modified":"2018-07-16T14:54:58","modified_gmt":"2018-07-16T18:54:58","slug":"potential-dna-damage-from-crispr-has-been-seriously-underestimated-study-finds","status":"publish","type":"post","link":"https:\/\/medicarereport.org\/?p=10952","title":{"rendered":"Potential DNA damage from CRISPR has been \u2018seriously underestimated,\u2019 study finds"},"content":{"rendered":"<p>(By Sharon Begley for ST<em>A<\/em>T)<\/p>\n<p class=\"big-cap-wrap danger-zone\"><span class=\"big-cap\">From the earliest days of the CRISPR-Cas9 era, scientists have known that the first step in how it\u00a0<a href=\"https:\/\/www.statnews.com\/2018\/04\/04\/how-crispr-works-visualized\/\">edits genomes<\/a>\u00a0\u2014 snipping DNA \u2014 creates an unholy mess: Cellular repairmen frantically try to fix the cuts by throwing random chunks of DNA into the breach and deleting other random bits.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/Nbt.4192\" target=\"_blank\" rel=\"noopener noreferrer\">Research<\/a>\u00a0published on Monday suggests that\u2019s only the tip of a Titanic-sized iceberg: CRISPR-Cas9 can cause significantly greater genetic havoc than experts thought, the study concludes, perhaps enough to threaten the health of patients who would one day\u00a0receive\u00a0<a href=\"https:\/\/www.statnews.com\/2018\/02\/21\/crispr-sickle-cell-clinical-trials\/\">CRISPR-based therapy<\/a>. <a href=\"https:\/\/www.statnews.com\/2018\/07\/16\/crispr-potential-dna-damage-underestimated\/\">Continue reading article here&#8230;<\/a><\/span><\/p>\n<p class=\"big-cap-wrap danger-zone\"><a href=\"https:\/\/medicarereport.org\/wp-content\/uploads\/2016\/09\/STAT-Logo.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4372\" src=\"https:\/\/medicarereport.org\/wp-content\/uploads\/2016\/09\/STAT-Logo-300x32.png\" alt=\"\" width=\"300\" height=\"32\" srcset=\"https:\/\/medicarereport.org\/wp-content\/uploads\/2016\/09\/STAT-Logo-300x32.png 300w, https:\/\/medicarereport.org\/wp-content\/uploads\/2016\/09\/STAT-Logo.png 453w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<pre>Notice: The link provided above connects readers to the full content of the posted article. The URL (internet address) for this link is valid on the posted date; medicarereport.org cannot guarantee the duration of the link\u2019s validity. Also, the opinions expressed in these postings are the viewpoints of the original source and are not explicitly endorsed by AMAC, Inc.; the AMAC Foundation, Inc.; or medicarereport.org.<\/pre>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(By Sharon Begley for STAT) From the earliest days of the CRISPR-Cas9 era, scientists have known that the first step<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,14],"tags":[],"class_list":["post-10952","post","type-post","status-publish","format-standard","hentry","category-emerging-health-issues","category-medical-technology"],"_links":{"self":[{"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/posts\/10952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/medicarereport.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10952"}],"version-history":[{"count":1,"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/posts\/10952\/revisions"}],"predecessor-version":[{"id":10953,"href":"https:\/\/medicarereport.org\/index.php?rest_route=\/wp\/v2\/posts\/10952\/revisions\/10953"}],"wp:attachment":[{"href":"https:\/\/medicarereport.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicarereport.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicarereport.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}